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What is PGD/PGS ?

Preimplantation Genetic Diagnosis (PGD), also known as Preimplantation Genetic Screening (PGS), refers to a reproductive technology procedure performed on embryos prior to implantation and pregnancy to detect chromosomal/genetic normalcy. The procedure is based upon the removal of cell(s) from an embryo on day 3 or 5 after fertilization.

PGD (PGS) is a way for couples to prevent a pregnancy affected by a genetic condition or chromosomal disorder, another way of prenatal diagnosis. This procedure is performed after a woman’s eggs has been retrieved and fertilized by sperm, thus always in association with assisted reproductive technology.

Why PGD/ PGS?

Many women have a risk to have a pregnancy with chromosome abnormalities, this risk does increase in relation to the woman’s age. With PGD a patient of advanced maternal age would have the option of analyzing the chromosomal integrity of their embryos prior to implantation and therefore less likely to be faced with potentially difficult decision making during an ongoing pregnancy. The parents can pursue PGD for aneuploidy, an embryo the wrong number of chromosomes such as Down syndrome (an extra chromosome 21), to optimize the chance of having a healthy baby.

Also some of our patients who experienced prior pregnancy loss want their embryos tested as chromosomal abnormalities are the most common cause of miscarriage. 50% of first trimester miscarriages are due to a chromosome abnormality. PGD is also an option for patients with a family history of inherited genetic disorders who need to have their embryos analyzed to exclude any affected embryos being transferred.

Examples of Chromosomal disorders diagnoses by PGS/PGS

  • Autosomal Trisomies (i.e., Down’s Syndrome)
  • Autosomal Monosomies
  • X, Y Numerical Disorders (Turner’s Syndrome, Kleinfelter’s Syndrome)
  • Translocations (Reciprocal or Robertsonian)
  • Deletions

Examples of Genetic disorders diagnoses by PGD/PGS

  • Cystic Fibrosis
  • Duchenne Muscular Dystrophy
  • Hemophilia A
  • Retinitis Pigmentosa
  • TaySachs Disease
  • Sickle Cell Anemia
  • Thalassemias
  • 119 Others

Does PGD affect pregnancy rates during IVF?

If you are considering PGD and IVF, you may be concerned about the risk of not being able to use all of your fertilized embryos. Some experts say that PGD will not affect the pregnancy rates of IVF. However, if an embryo is found to have genetic or chromosomal abnormalities, it might not be implanted into the uterus. This would reduce the number of embryos that can be transferred.

Not a perfect process

Sometimes doctors will identify an embryo or fetus to be at risk for a genetic disorder, but the baby may grow up without ever showing signs of the disease or abnormality.

Embryos that do have problems are sometimes misdiagnosed as healthy, and then transferred to the female. A baby could then be born with unexpected problems.

In addition, doctors can mistakenly identify a healthy embryo as abnormal, causing a perfectly healthy embryo to be discarded. Experts recommend that if a couple’s embryos show no genetic or chromosomal abnormalities during PGD, and the woman gets pregnant, more testing should be done during the pregnancy to make sure the baby is healthy.

Gender Selection

Gender selection of the baby is illegal in India and not offered by Go IVF Surrogacy or any of its clinics.




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